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KMID : 0605619990060020176
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Journal of Korean Society of Biological Psychiatry
1999 Volume.6 No. 2 p.176 ~ p.188
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Effects of Alcohol on Neurocognitive Function, Psychomotor Performance and Subjective Response in Koreans with Different ALDH2 Genotypes
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1신일선/1Il Seon Sin
1윤진상/1김현/1이형영/2윤도현/3이훈/4정재성/1Jin Sang Yoon/1Hyun Kim/1Hyung Yung Lee/2Bo Hyun Yoon/3Hoon Lee/4Jae Sung Jung
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Abstract
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Objective : The purpose of this study was to evaluated the effects of alcohol on
neurocognitive function, psychomotor performance and subjective response in healthy
Korean adults with different ALDH2 genotypes.
Method : A total of 24 males, half with active
ALDH2*1/2*1 and the other with inactive
ALDH2*1/2*1, was selected through genotyping using
restriction fragment length polymorphism. In a double-blind, placebo-controlled
cross-over design, each subject consumed 0.5g/kg dose of alcohol, given as a mixture of
40% vodka and orange juice, and placebo(orange juice) on two separate occasions on an
average of weekly intervals. The blood alcohol concentrations(BACs) were measured
using a breath analyzer at baseline and at 30, 60 minutes after drinking. P300s were
measured at baseline and at 30 minutes after alcohol and placebo intake. Vital signs and
psychomotor performance[Critical Flicker Fusion Threshold(CFFT), Choice Reaction
Time(CRT), Digit Symbol Substitution(DSS)] were measured at baseline and at 60
minutes after alcohol and placebo intake. Subjective responses were measured at the end
of the study. The statistical analysis focused on whether there were any differences
between groups with different ALDH2 genotypes.
Results : The major results are as follows.
1) BACs in inactive group were overall equivalent to those in the active group. Only in
terms of time, BACs were significantly higher overall at 30 minutes than at 60 minutes
after alcohol intake.
2) Pulse rates were significantly increased after alcohol intake compared with placebo,
and the increase was greater in the inactive than in the active group.
3) P300 latencies in leads Fz(frontal), Cz(cental) and Pz(parietal) were significantly
increased after alcohol intake compared to placebo, and the increase was greater in the
inactive than in the active group. P300 amplitudes in leads Cz and Pz were significantly
decreased overall after alcohol intake compared to placebo.
4) Compared with placebo, alcohol produced significant effect on the psychomotor
performance : impairment in the inactive group, improvement in the active group.
5) Compared with placebo, alcohol significantly induced a negative or an intense effect
on the subjective responses in the inactive group, but little negative and even a
somewhat positive effect in the active group.
Conclusions : These results suggest that ALDH isozyme variance might be an
important factor to determine the effects of acute dose of alcohol on the various
psychobehavioural functions and also to determine the alcohol use pattern and to predict
the future development of alcohol overuse and/or abuse.
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KEYWORD
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